Mange sovemedisiner er sterkt vanedannende og bør bare brukes i kortere perioder. Som regel mister vanedannende sovemedisiner effekten når de brukes sammenhengende in excess of lang tid. Sovemidler av antihistamin-typen gir ikke avhengighet.Disse preparatene har også mindre negativ innvirkning på søvnstadiene og gir mindre grad av avhengighet
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